The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Medicines for high blood pressure Because Baclofen can cause drowsiness, other medicines that also cause drowsiness may increase this effect of Baclofen. Every prescription drug has side effects and can seriously harm your health. Metabolism In study using radiolabeled baclofen, approximately 85 of the dose was excreted unchanged in the kupiti zeliscne baclofen urine and feces. Conclusion: Once-daily baclofen SR and GRS are efficacious, convenient, and better-tolerated alternatives to baclofen IR in patients with neurogenic spasticity. Avoid abrupt withdrawal of the abrupt withdrawal of intrathecal baclofen has resulted in severe sequelae hyperpyrexia, obtundation, rebound exaggerated spasticity, muscle rigidity, and rhabdomyolysis leading to organ failure and some fatalities.