Boustani co-authored clinical review of existing evidence on the effects of various drugs on the cognition of older people in the hospital. In comparison, the human AUC value for 2-mg dose administered twice daily is estimated at 34. Confusion, disorientation, delusion have been reported after tolterodine therapy was initiated in patients taking cholinesterase inhibitors for the treatment of dementia. Study subjects approximately equal representation of CYP2D6 extensive for detrol online metabolizers EMs and poor metabolizers PMs completed sequential 4-day periods of dosing with moxifloxacin 400 mg QD, tolterodine mg BID, tolterodine mg BID, and placebo. No single QT correction method is known to be more valid than others. Ask your doctor about the effect of medications on your heart, on your liver and on your kidneys, said Boustani, an associate professor of medicine. In the presence of ketoconazole, the mean Cmax and AUC of tolterodine increased by and.