Encyclopedia of Public Health: Tamoxifen Top Home Library Health Public Health Encyclopedia Tamoxifen, selective estrogen-receptor modulator, is an oral medication exhibiting both estrogen agonist and antagonist effects. Against the advice of its creator, Sir Charles Dodd, between four and six million American and European women and 10,000 Australian women innocently used DES for the prevention of miscarriage and pregnancy complications. The purpose of this double-blind study is to evaluate the use of tamoxifen and raloxifene another type of SERM over five-year period in 22,000 postmenopausal women 35 years or older who are at high risk for developing breast cancer. The decision regarding therapy with NOLVADEX for the reduction in breast cancer incidence should be based upon an individual assessment of the benefits and risks of NOLVADEX therapy. After watching these women for years, the study found that, compared with the women taking the placebo, those who tamoxifen fedex ohne rezept took tamoxifen had: About half the risk of invasive breast cancer.